ABSTRACT Due to the heterogeneity of the current terminal and network infrastructures, multimedia content needs to be adapted to specific capabilities of these terminals and network devices. Furthermore, user preferences and user environment characteristics must also be taken into consideration. The problem becomes even more complex by the diversity of multimedia content types and encoding formats. In order to meet this heterogeneity and to be applicable to different coding formats, the adaptation must be performed in a generic and interoperable way. As a response to this problem and in the context of MPEG-21, we present an approach which uses XML to describe the high-level structure of a multimedia resource in a generic way, i.e., how the multimedia content is organized, for instance in layers, frames, or scenes. For this purpose, a schema for XML-based bitstream syntax descriptions (generic Bitstream Syntax Descriptions or gBSDs) has been developed. A gBSD can describe the high-level structure of a multimedia resource in a coding format independent way. Adaptation of the resource is based on elementary transformation instructions formulated with respect to the gBSDs. These instructions have been separated from the gBSDs in order to use the same descriptions for different adaptations, e.g., temporal scaling, SNR scaling, or semantic adaptations. In the MPEG-21 framework, those adaptations can be steered for instance by the network characteristics and the user preferences. As a result, it becomes possible for coding format agnostic adaptation engines to transform media bitstreams and associated descriptions to meet the requirements imposed by the network conditions, device capabilities, and user preferences. Keywords: Multimedia, Adaptation, Interoperability, XML, MPEG-21, Digital Item Adaptation